Author:
Wang Daquan,Wang Changyu,Liang Zhenxing,Lei Wangrui,Deng Chao,Liu Xiaoli,Jiang Shuai,Zhu Yanli,Zhang Shaofei,Yang Wenwen,Chen Ying,Qiu Yao,Meng Lingjie,Yang Yang
Abstract
Abstract
Background
Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown.
Results
NanoFe was prepared via the liquid-phase reduction method and functionalized with the biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed a mouse model of septic myocardial injury by challenging with cecal ligation and puncture (CLP). Our findings demonstrated that nanoFe has a significant protective effect on CLP-induced septic myocardial injury. This may be achieved by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis.
Conclusions
The results provide a theoretical basis for the application strategy and combination of nanoFe in sepsis and septic myocardial injury.
Graphical Abstract
Funder
National Natural Science Foundation of China
the National Postdoctoral Program for Innovative Talent
Innovation Capability Strong Foundation Plan of Xi'an City
Natural Science Foundation of Shaanxi Province
Key Research and Development Program of Shaanxi
Major Research Projects of Xi'an Science and Technology Plan
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
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