Author:
Sun Yingxue,Zhai Wenhui,Liu Xiaojun,Song Xiangyi,Gao Xiaonan,Xu Kehua,Tang Bo
Abstract
Abstract
Background
Tumor recurrence in patients after surgery severely reduces the survival rate of surgical patients. Targeting and killing recurrent tumor cells and tissues is extremely important for the cancer treatment.
Results
Herein, we designed a nano-biomimetic photothermal-controlled drug-loading platform HepM-TSL with good targeting ability and immunocompatibility for the treatment of recurrent hepatocellular carcinoma. HepM-TSL can accurately target the recurrent tumor area with the aid of the cloaked homotypic cell membrane and release the chemotherapy drugs in a controlled manner. In vivo results have confirmed that HepM-TSL loaded with drugs and photosensitizer achieves the synergistic treatment of recurrent hepatocellular carcinoma with good therapeutic effect and slight side effects.
Conclusion
Accordingly, HepM-TSL provides a sound photothermal-chemotherapy synergistic strategy for the treatment of other recurrent cancers besides of recurrent hepatocellular carcinoma.
Funder
the National Natural Science Foundation of China
the Key Research and Development Program of Shandong Province
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Reference33 articles.
1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
2. Lee EC, Kim SH, Park H, Lee SD, Lee S, Park S. Survival analysis after liver resection for hepatocellular carcinoma: a consecutive cohort of 1002 patients. J Clin Gastroenterol Hepatol. 2017;32:1055–63.
3. Erridge S, Pucher PH, Markar SR, Malietzis G, Athanasiou T, Darz A, et al. Meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma. Br J Surg. 2017;104:1433–42.
4. Wang FS, Fan JG, Zhang Z, Gao B, Wang HY. The global burden of liver disease: the major impact of China. Hepatology. 2014;60:2009–108.
5. Paola B, Federica T, Greta C, Teresa R, Carlo LV, Matteo M, et al. Global trends and predictions in hepatocellular carcinoma mortality. J Hepatol. 2017;67:302–9.
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