Author:
Xiong Linjin,Wei Yumeng,Jia Qiang,Chen Jinglin,Chen Tao,Yuan Jiyuan,Pi Chao,Liu Huiyang,Tang Jia,Yin Suyu,Zuo Ying,Zhang Xiaomei,Liu Furong,Yang Hongru,Zhao Ling
Abstract
AbstractColorectal cancer (CRC) has high incidence and mortality rates and is one of the most common cancers of the digestive tract worldwide. Metastasis and drug resistance are the main causes of cancer treatment failure. Studies have recently suggested extracellular vesicles (EVs) as a novel mechanism for intercellular communication. They are vesicular particles, which are secreted and released into biological fluids, such as blood, urine, milk, etc., by a variety of cells and carry numerous biologically active molecules, including proteins, nucleic acids, lipids, metabolites, etc. EVs play a crucial part in the metastasis and drug resistance of CRC by delivering cargo to recipient cells and modulating their behavior. An in-depth exploration of EVs might facilitate a comprehensive understanding of the biological behavior of CRC metastasis and drug resistance, which might provide a basis for developing therapeutic strategies. Therefore, considering the specific biological properties of EVs, researchers have attempted to explore their potential as next-generation delivery systems. On the other hand, EVs have also been demonstrated as biomarkers for the prediction, diagnosis, and presumed prognosis of CRC. This review focuses on the role of EVs in regulating the metastasis and chemoresistance of CRC. Moreover, the clinical applications of EVs are also discussed.
Graphical Abstract
Funder
the cooperation Project of Central Nervous System Drug Key Laboratory of Sichuan Province
the Major R&D Plan Joint Innovation Project
Key Research and Development Projectors of Luzhou
the central government guides the local science and technology development special fund
the Youth Science and Technology Innovation Research Team of the Science and Technology Department of Sichuan province of China
the Science and Technology Innovation Team from Jiucheng Science and Technology Talent Cultivation Plan in Luzhou
Chongqing Traditional Chinese Medicine Inheritance and Innovation Team Construction Project "Traditional Chinese Medicine New Drug and Safety Research Inheritance and Innovation Team"
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering