CD44-targeting hyaluronic acid-selenium nanoparticles boost functional recovery following spinal cord injury

Author:

Luo Wenqi,Li Yueying,Zhao Jianhui,Niu Renrui,Xiang Chunyu,Zhang Mingyu,Xiao Chunsheng,Liu Wanguo,Gu Rui

Abstract

Abstract Background Therapeutic strategies based on scavenging reactive oxygen species (ROS) and suppressing inflammatory cascades are effective in improving functional recovery after spinal cord injury (SCI). However, the lack of targeting nanoparticles (NPs) with powerful antioxidant and anti-inflammatory properties hampers the clinical translation of these strategies. Here, CD44-targeting hyaluronic acid-selenium (HA-Se) NPs were designed and prepared for scavenging ROS and suppressing inflammatory responses in the injured spinal cord, enhancing functional recovery. Results The HA-Se NPs were easily prepared through direct reduction of seleninic acid in the presence of HA. The obtained HA-Se NPs exhibited a remarkable capacity to eliminate free radicals and CD44 receptor-facilitated internalization by astrocytes. Moreover, the HA-Se NPs effectively mitigated the secretion of proinflammatory cytokines (such as IL-1β, TNF-α, and IL-6) by microglia cells (BV2) upon lipopolysaccharide-induced inflammation. In vivo experiments confirmed that HA-Se NPs could effectively accumulate within the lesion site through CD44 targeting. As a result, HA-Se NPs demonstrated superior protection of axons and neurons within the injury site, leading to enhanced functional recovery in a rat model of SCI. Conclusions These results highlight the potential of CD44-targeting HA-Se NPs for SCI treatment.

Funder

Youth Support Programmed Project of China Japan Union Hospital of Jilin University

National Natural Science Foundation of China

Jilin Provincial Finance Program

Jilin Provincial Science and Technology Program

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering

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