Author:
Hong Linjun,Zang Xupeng,Hu Qun,He Yanjuan,Xu Zhiqian,Xie Yanshe,Gu Ting,Yang Huaqiang,Yang Jie,Shi Junsong,Zheng Enqin,Huang Sixiu,Xu Zheng,Liu Dewu,Cai Gengyuan,Li Zicong,Wu Zhenfang
Abstract
AbstractMost pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are considered potential endogenous nanomedicines because of their unique biological functions. However, the limited supply of ULF-EVs prevents their development and application in infertility diseases such as implantation failure. In this study, pigs were used as a human biomedical model, and ULF-EVs were isolated from the uterine luminal. We comprehensively characterized the proteins enriched in ULF-EVs and revealed their biological functions in promoting embryo implantation. By exogenously supplying ULF-EVs, we demonstrated that ULF-EVs improve embryo implantation, suggesting that ULF-EVs are a potential nanomaterial to treat implantation failure. Furthermore, we identified that MEP1B is important in improving embryo implantation by promoting trophoblast cell proliferation and migration. These results indicated that ULF-EVs can be a potential nanomaterial to improve embryo implantation.
Funder
National Natural Science Foundation of China
Guangdong Basic and Applied Basic Research Foundation
Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Cited by
3 articles.
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