Author:
Zhai Bing-Tao,Sun Jing,Shi Ya-Jun,Zhang Xiao-Fei,Zou Jun-Bo,Cheng Jiang-Xue,Fan Yu,Guo Dong-Yan,Tian Huan
Abstract
AbstractNorcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD), the main anticancer active ingredient isolated from traditional Chinese medicine Mylabris. NCTD has been approved by the State Food and Drug Administration for the treatment of various solid tumors, especially liver cancer. Although NCTD greatly reduces the toxicity of CTD, there is still a certain degree of urinary toxicity and organ toxicity, and the poor solubility, short half-life, fast metabolism, as well as high venous irritation and weak tumor targeting ability limit its widespread application in the clinic. To reduce its toxicity and improve its efficacy, design of targeted drug delivery systems based on biomaterials and nanomaterials is one of the most feasible strategies. Therefore, this review focused on the studies of targeted drug delivery systems combined with NCTD in recent years, including passive and active targeted drug delivery systems, and physicochemical targeted drug delivery systems for improving drug bioavailability and enhancing its efficacy, as well as increasing drug targeting ability and reducing its adverse effects.
Graphical Abstract
Funder
National Natural Science Foundation of China
Natural Science Basic Research Program Project of Shaanxi Province
Key Scientific Research Project of Shaanxi Provincial Department of Education
School-level Scientific Research Project of Shaanxi University of Traditional Chinese Medicine
the Disciplinary Innovation Team Construction Project of Shaanxi University of Traditional Chinese Medicine
Scientific Research Project of Xi'an Administration of Traditional Chinese Medicine
Scientific Research Project of Xi'an Municipal Health Commission
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Cited by
13 articles.
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