Author:
Du Shuang,Guan Yucheng,Xie Aihua,Yan Zhao,Gao Sijia,Li Weirong,Rao Lang,Chen Xiaojia,Chen Tongkai
Abstract
AbstractExtracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural carriers for therapeutic agents and drugs, and have many advantages over conventional nanocarriers, including their low immunogenicity, good biocompatibility, natural blood–brain barrier penetration, and capacity for gene delivery. This review first introduces the classification of EVs and then discusses several currently popular methods for isolating and purifying EVs, EVs-mediated drug delivery, and the functionalization of EVs as carriers. Thereby, it provides new avenues for the development of EVs-based therapeutic strategies in different fields of medicine. Finally, it highlights some challenges and future perspectives with regard to the clinical application of EVs.
Graphical Abstract
Funder
Key Fields of Biomedicine and Health Foundation of Colleges and Universities
Guangdong Basic and Applied Basic Research Foundation
Basic and Applied Basic Research Foundation of Guangdong Province
National Natural Science Foundation of China
the Science and Technology Development Fund, Macau SAR
University of Macau
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Reference263 articles.
1. Jackson KK, Mata C, Marcus RK. A rapid capillary-channeled polymer (C-CP) fiber spin-down tip approach for the isolation of plant-derived extracellular vesicles (PDEVs) from 20 common fruit and vegetable sources. Talanta. 2022;252:123779.
2. Witwer KW, Wolfram J. Extracellular vesicles versus synthetic nanoparticles for drug delivery. Nat Reviews Mater. 2021;6:103–6.
3. Zhang X, Zhang HB, Gu JM, Zhang JY, Shi H, Qian H, Wang DQ, Xu WR, Pan JM, Santos HA. Engineered extracellular vesicles for cancer therapy. Adv Mater. 2021;33:25.
4. Van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28.
5. Wiklander OPB, Brennan MA, Lotval J, Breakefield XO, El Andaloussi S. Advances in therapeutic applications of extracellular vesicles. Sci Transl Med. 2019;11:15.
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