Author:
Cai Jiaying,Zhang Hui,Hu Yangnan,Huang Zhichun,Wang Yan,Xia Yu,Chen Xiaoyan,Guo Jiamin,Cheng Hong,Xia Lin,Lu Weicheng,Zhang Chen,Xie Jingdun,Wang Huan,Chai Renjie
Abstract
AbstractRepair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons and regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity and internal-facing longitudinal grooves and explore its function in SCI repair. It is found that the resultant grooved GelMA-MXene hydrogel could effectively promote the neural stem cells (NSCs) adhesion, directed proliferation and differentiation in vitro. Additionally, when the GelMA-MXene conduit loaded with NSCs (GMN) is implanted into the injured spinal cord site, effective repair capability for the complete transection of SCI was demonstrated. The GMN group shows remarkable nerve recovery and significantly higher BBB scores in comparison to the other groups. Therefore, GMN with the microgroove structure and loaded with NSCs is a promising strategy in treating SCI.
Funder
National Key Research and Development Program of China
National Key R&D Program of China
Strategic Priority Research Program of the Chinese Academy of Science
National Natural Science Foundation of China
Natural Science Foundation from Jiangsu Province
Science and Technology Department of Sichuan Province
Guangdong Basic and Applied Basic Research Foundation
Shenzhen Fundamental Research Program
Open Research Fund of State Key Laboratory of Genetic Engineering, Fudan University
Guangdong Natural Science Foundation for Distinguished Young Scholars
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Cited by
25 articles.
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