Author:
Tang Ling,Peng Lin,Tan Chao,Liu Huai,Chen Pan,Wang Hui
Abstract
AbstractHOXA9 functioning as a transcription factor is one of the members of HOX gene family, which governs multiple cellular activities by facilitating cellular signal transduction. In addition to be a driver in AML which has been widely studied, the role of HOXA9 in solid tumor progression has also received increasing attention in recent years, where the aberrant expression of HOXA9 is closely associated with the prognosis of patient. This review details the signaling pathways, binding partners, post-transcriptional regulation of HOXA9, and possible inhibitors of HOXA9 in solid tumors, which provides a reference basis for further study on the role of HOXA9 in solid tumors.
Funder
Scientific Research Project of Hunan Provincial Health Commission
National Natural Science Foundation of China
Natural Science Foundation of Hunan Province
Hunan Cancer Hospital Climb Plan
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Cited by
5 articles.
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