Author:
Gramegna Andrea,Misuraca Sofia,Lombardi Andrea,Premuda Chiara,Barone Ivan,Ori Margherita,Amati Francesco,Retucci Mariangela,Nazzari Erica,Alicandro Gianfranco,Ferrarese Maurizio,Codecasa Luigi,Bandera Alessandra,Aliberti Stefano,Daccò Valeria,Blasi Francesco
Abstract
Abstract
Introduction
Over the last ten years an increasing prevalence and incidence of non-tuberculous mycobacteria (NTM) has been reported among patients with cystic fibrosis (CF) Viviani (J Cyst Fibros, 15(5):619–623, 2016). NTM pulmonary disease has been associated with negative clinical outcomes and often requires pharmacological treatment. Although specific guidelines help clinicians in the process of diagnosis and clinical management, the focus on the multidimensional assessment of concomitant problems is still scarce.
Main body
This review aims to identify the treatable traits of NTM pulmonary disease in people with CF and discuss the importance of a multidisciplinary approach in order to detect and manage all the clinical and behavioral aspects of the disease. The multidisciplinary complexity of NTM pulmonary disease in CF requires careful management of respiratory and extra-respiratory, including control of comorbidities, drug interactions and behavioral factors as adherence to therapies.
Conclusions
The treatable trait strategy can help to optimize clinical management through systematic assessment of all the aspects of the disease, providing a holistic treatment for such a multi-systemic and complex condition.
Funder
Regione Lombardia
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Publisher
Springer Science and Business Media LLC