Author:
Qi Ya-Nan,Liu Zhu,Hong Lian-Lian,Li Pei,Ling Zhi-Qiang
Abstract
AbstractRNA modification has recently become a significant process of gene regulation, and the methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification, methylating various types of RNAs, including mRNA, tRNA, microRNA, rRNA, and mitochondrial RNAs. METTL proteins consist of a unique seven-beta-strand domain, which binds to the methyl donor SAM to catalyze methyl transfer. The most typical family member METTL3/METTL14 forms a methyltransferase complex involved in N6-methyladenosine (m6A) modification of RNA, regulating tumor proliferation, metastasis and invasion, immunotherapy resistance, and metabolic reprogramming of tumor cells. METTL1, METTL4, METTL5, and METTL16 have also been recently identified to have some regulatory ability in tumorigenesis, and the rest of the METTL family members rely on their methyltransferase activity for methylation of different nucleotides, proteins, and small molecules, which regulate translation and affect processes such as cell differentiation and development. Herein, we summarize the literature on METTLs in the last three years to elucidate their roles in human cancers and provide a theoretical basis for their future use as potential therapeutic targets.
Funder
Zhejiang Medical and Health Science and Technology Project
Zhejiang Provincial Public Welfare Technology Research Plan Project
Program for Innovation Research Team (in Science and Technology) in University of Henan Province
National Natural Science Foundation of China
National Health Commission Science Research Fund-Zhejiang Provincial Health Key Science and Technology Plan Project
Key Projects from Zhejiang Provincial Natural Science Foundation
General Project from Henan Provincial Natural Science Foundation
General Project from Zhejiang Provincial Natural Science Foundation
Leading Talents in Scientific and Technological Innovation from Zhejiang Provincial Ten Thousand Talents Plan
Zhejiang Province Health Leader Talent
Major Training Personnel from Zhejiang Provincial Program for Training and Development Project for 151 Talents
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Biology,Hematology
Cited by
6 articles.
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