Author:
Yang Cheng,Zhang Jiayu,Ma Yukui,Wu Chunfu,Cui Wei,Wang Lihui
Abstract
AbstractA number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance might involved in changes in gene expression without changing genotypes, which is similar to epigenetic modification. Some studies indicated that targeting histone methyltransferase can reverse drug resistance. Hence, the use of histone methyltransferase inhibitors or histone demethylase inhibitors opens new therapeutic approaches for cancer treatment. While the relationship between histone methyltransferase and tumor resistance has been determined, there is a lack of updated review on the association between them. In this review, we summarized the mechanisms of histone methyltransferases in cancer drug resistance and the therapeutic strategies of targeting histone methyltransferase to reverse drug resistance.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Liaoning Province
Xingliao Talents Program of Liaoning Province
Liaoning Province innovation talent project
Youth Science and Technology Innovation Leader Program of Shenyang
Publisher
Springer Science and Business Media LLC
Cited by
41 articles.
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