Author:
Wang Yaxian,Zhong Xinyang,He Xuefeng,Hu Zijuan,Huang Huixia,Chen Jiayu,Chen Keji,Zhao Senlin,Wei Ping,Li Dawei
Abstract
AbstractColorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex immune landscape of the hepatic tumour microenvironment is essential for the development of a premetastatic niche and for the colonisation and metastasis of CRC cells; thus, an in-depth understanding of these mechanisms can provide effective immunotherapeutic targets for CRLM. This review summarises recent studies on the immune landscape of the tumour microenvironment of CRLM and highlights therapeutic prospects for targeting the suppressive immune microenvironment of CRLM.
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC