Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops

Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops — a case report

Published:2023-09-16 Issue:1 Volume:13 Page:
ISSN:1869-5760
Container-title:Journal of Ophthalmic Inflammation and Infection
language:en
Short-container-title:J Ophthal Inflamm Infect

Author:

Elhardt Carolin,Wolf Armin,Wertheimer Christian Maximilian

Abstract

Abstract Background This case report describes the course and therapeutic management of a fast-spreading bacterial keratitis caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa). Case presentation A 27-year-old male contact lens wearer presented with a multi-resistant, fast spreading P. aeruginosa keratitis. After initial resistance to various antibiotic therapies, testing revealed a MDR P. aeruginosa. The keratitis was treated successfully with specially prepared 50 mg/ml off-label meropenem eye drops for 18 days as well as systemic meropenem for seven days with rapid improvement of the corneal infiltrate. Conclusion This case report demonstrates the combination of topical and systemic meropenem as a useful treatment option for corneal ulcers caused by MDR P. aeruginosa.

Funder

Universitätsklinikum Ulm

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Ophthalmology

Link

https://link.springer.com/content/pdf/10.1186/s12348-023-00363-0.pdf

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