Examining ALS: reformed PCA and random forest for effective detection of ALS

Abstract

AbstractALS (Amyotrophic Lateral Sclerosis) is a fatal neurodegenerative disease of the human motor system. It is a group of progressive diseases that affects the nerve cells in the brain and spinal cord that control the muscle movement of the body hence, detection and classification of ALS at the right time is considered to be one of the vital aspects that can save the life of humans. Therefore, in various studies, different AI techniques are used for the detection of ALS, however, these methods are considered to be ineffectual in terms of identifying the disease due to the employment of ineffective algorithms. Hence, the proposed model utilizes Modified Principal Component Analysis (MPCA) and Modified Random Forest (MRF) for performing dimensionality reduction of all the potential features considered for effective classification of the ALS presence and absence of ALS causing mutation in the corresponding gene. The MPCA is adapted for capturing all the Low-Importance Data transformation. Furthermore, The MPCA is objected to performing three various approaches: Covariance Matrix Correlation, Eigen Vector- Eigenvalue decomposition, and selecting the desired principal components. This is done in aspects of implying the LI (Lower-Importance) Data Transformation. By choosing these potential components without any loss of features ensures better viability of selecting the attributes for ALS-causing gene classification. This is followed by the classification of the proposed model by using Modified RF by updating the clump detector technique. The clump detector is proceeded by clustering approach using K-means, and the data reduced by their dimension are grouped accordingly. These clustered data are analyzed either for ALS causing or devoid of causing ALS. Finally, the model’s performance is assessed using different evaluation metrics like accuracy, recall, F1 score, and precision, and the proposed model is further compared with the existing models to assess the efficacy of the proposed model.