Abstract
Abstract
Background
Uterine angioleiomyoma is benign tumor that composed of smooth muscle cells and thick-walled vessels. It is a very rare condition reported to present as lower abdominal mass, accompanied by dysmenorrhea and hypermenorrhea. However, its clinical presentation is not known.
Case presentation
We report the case of a 44-year-old Japanese woman who developed severe anemia with disseminated intravascular coagulation without obvious external bleeding. The patient had a huge abdominal mass of over 20 cm in size, which was thought to be a uterine tumor. She received daily blood transfusions and her condition improved rapidly after she underwent hysterectomy. Pathological examination of the tumor revealed spindle-shaped cells with little atypia and mitosis, and numerous large vessels with smooth muscle and thrombus in the vessels.
Conclusions
Uterine angioleiomyoma was identified as the cause of the coagulation abnormality. CCND2 and AR gene amplification was detected in the tumor. Uterine tumors that present with coagulopathy despite a clinical course suggestive of benign disease should undergo differential diagnosis for uterine angioleiomyoma.
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynecology,Reproductive Medicine,General Medicine
Reference12 articles.
1. Blaustein’s Pathology of the Female Genital Tract seventh Edition: 10. Mesenchymal Tumors of the Uterus P535–647.
2. Taylor FB, Toh CH, Hoots WK, Wada H, Levi M. (ISTH) SSoDICDotISoTaH: Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327–30.
3. Aota T, Wada H, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Asakura H, et al. An evaluation of the modified diagnostic criteria for dic established by the Japanese society of thrombosis and hemostasis. Clin Appl Thromb Hemost. 2017;23(6):579–84.
4. Seth A, Mathur A. Angioleiomyoma of uterus and cervix: a rare report of two cases. J Midlife Health. 2021;12(2):179–84.
5. Gorginzadeh M, Tahermanesh K, Hanjani S, Khorshidizadeh A, Allahqoli L, Sadeghipour A, Anvari-Yazdi AF. Uterine intracavitary angioleiomyoma. J Obstet Gynaecol. 2020;40(8):1186–8.