Author:
Ye Jiayin,Gao Cheng,Liang Yong,Hou Zongliu,Shi Yufang,Wang Ying
Abstract
AbstractAdipose tissues are essential for actively regulating systemic energy balance, glucose homeostasis, immune responses, reproduction, and longevity. Adipocytes maintain dynamic metabolic needs and possess heterogeneity in energy storage and supply. Overexpansion of adipose tissue, especially the visceral type, is a high risk for diabetes and other metabolic diseases. Changes in adipocytes, hypertrophy or hyperplasia, contribute to the remodeling of obese adipose tissues, accompanied by abundant immune cell accumulation, decreased angiogenesis, and aberrant extracellular matrix deposition. The process and mechanism of adipogenesis are well known, however, adipose precursors and their fate decision are only being defined with recent information available to decipher how adipose tissues generate, maintain, and remodel. Here, we discuss the key findings that identify adipose precursors phenotypically, with special emphasis on the intrinsic and extrinsic signals in instructing and regulating the fate of adipose precursors under pathophysiological conditions. We hope that the information in this review lead to novel therapeutic strategies to combat obesity and related metabolic diseases.
Funder
the National Key R&D Program of China
the Scientific Innovation Project of the Chinese Academy of Sciences
the National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Developmental Biology
Cited by
4 articles.
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