Author:
Ruan Yanping,Xie Zan,Liu Xiaowei,He Yihua
Abstract
Abstract
Objective
Current studies have suggested that fetal congenital heart diseases (CHDs) are caused by various factors. However, few data in this field is available in China.
This study aimed to detect associated factors of prenatally diagnosed fetal CHD in a large sample in China.
Study design
Pregnant women who underwent fetal echocardiography were recruited in our hospital between May 2018 and September 2019. The maternal sociodemographic and lifestyle characteristics and some fetal factors were obtained. We used forward stepwise logistic regression analysis to assess risk of fetal CHD associated with various factors.
Results
A total of 5024 subjects were enrolled, of whom 875 had CHD fetuses. Among the fetal CHD group (N = 875), critical CHDs account for 27%, of which Tetralogy of Fallot is the most (7.1%), followed by coarctation of aorta (4.0%), double-outlet right ventricle (2.9%). The forward stepwise logistic regression models revealed that history of spontaneous abortion (OR = 1.59, 95% CI 1.33–1.91, P = 0.000), upper respiratory tract infection during early pregnancy (OR = 1.30, 95% CI 1.04–1.62, P = 0.020), mental stress during early pregnancy (OR = 2.37, 95% CI 1.15–4.91, P = 0.020), single umbilical artery (OR = 2.30, 95% CI 1.18–4.51, P = 0.015), and paternal smoking (OR = 1.21, 95% CI 1.02–1.44, P = 0.027) are positively associated with an increased risk of fetal CHD.
Conclusion
We identified several factors positively associated with fetal CHD. These findings suggest that it is important to strengthen healthcare and prenatal counseling for women with these factors.
Funder
National Key R&D Program of China
Yantai Science and Technology Innovation Development Project
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Reference32 articles.
1. GBD 2017 Congenital Heart Disease Collaborators.Global, regional, and national burden of congenital heart disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Child Adolesc Health. Lancet Child Adolesc Health 2020;4(3):185–200.
2. Zhao QM, Liu F, Wu L, et al. Prevalence of congenital heart disease at live birth in China. J Pediatr. 2019;204:53–8.
3. Tennant PW, Pearce MS, Bythell M, et al. 20-year survival of children born with congenital anomalies: a population-based study. Lancet. 2010;375(9715):649–56.
4. Wren C, Irving CA, Griffiths JA, et al. Mortality in infants with cardiovascular malformations. Eur J Pediatr. 2012;171(2):281–7.
5. Bruneau BG. The developmental genetics of congenital heart disease. Nature. 2008;451(7181):943–8.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献