Acute liver failure caused by Amanita verna: a case series and review of the literature

Author:

Wu Jianlong,Gong Xueyi,Hu Zemin,Sun Qiang

Abstract

Abstract Background Amanita verna is one of the most harmful wild fungi in China. Amanita verna poisoning occurs every year, and the mortality is as high as 50%. However, its clinical manifestations are complex and diverse. Case presentation In March 2019, three patients took a large amount of Amanita, and one of them received liver transplantation in Zhongshan hospital, Sun Yat-sen University. All patients had vomiting and diarrhea 8–12 h after eating wild mushrooms (Amanita). The patients were initially diagnosed with Amanita poisoning. One case (case 3) was complicated and diagnosed as mushroom poisoning (fatal Amanita), toxic hepatitis, acute liver failure, toxic encephalopathy, hemorrhagic colitis, toxic myocarditis, disseminated intravascular coagulation (DIC) and pregnancy. The general clinical data of all patients were recorded, who received early treatment such as hemodialysis, artificial liver plasma exchange, hormone shock and anti-infection. One case (case 1) recovered smoothly after liver transplantation, and the indexes of liver, kidney, coagulation function and infection were improved. The other two cases died of intracerebral hemorrhage. Conclusion Liver transplantation is an effective method for the treatment of acute liver failure caused by mushroom poisoning and can improve the survival rate of patients with toxic liver failure.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Surgery

Reference25 articles.

1. Kirchlechner R, Casutt M, Heywang U, Schwarz MW. Use of acetylcysteine as the life-saving antidote in Amanita phalloides (Death Cap) poisoning. Arzneimittelforschung. 1999;49(12):1044–7.

2. Geng J, Cao Z, Ma X, Shi Y, Wang Y, Pan Q. Mushroom poisoning: an overlooked cause of acute liver injury in China. Liver Int. 2016;37(3):468–9.

3. Lee HY, Park CW, Cho JH, Cheon SB, Moon JB. A case of Naematololma Fasciculare poisoning due to misidentification as an edible mushroom. J Korean Soc Emerg Med. 2011;22(2):181–3.

4. Diaz JH. Amatoxin-containing mushroom poisonings: species, toxidromes, treatments, and outcomes. Wilderness Environ Med. 2018;29(1):111.

5. Sun J, Li HJ, Zhang HS, Zhang YZ, Xie JW, Ma PB, et al. Investigating and analyzing three cohorts of mushroom poisoning caused by Amanita exitialis in Yunnan, China. Hum Exp Toxicol. 2017;2:960327117721960.

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Plasma exchange plus glucocorticoids in the treatment of immune checkpoint inhibitor‐induced myocarditis: A case series and review;Clinical Cardiology;2023-09-12

2. An outbreak of Amanita exitialis poisoning;Clinical Toxicology;2023-03-15

3. Malicious Mushrooms;Gastro Hep Advances;2023

4. Mushroom Poisoning and Treatments;Highlights in Science, Engineering and Technology;2022-12-30

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3