Abstract
AbstractThe incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated at approximately 5% of the population. Celiac disease (CD), dermatitis herpetiformis (DH), gluten ataxia (GA), wheat allergy (WA), and non-celiac gluten sensitivity (NCGS) are the five major GRDs that present with a wide range of clinical manifestations. The diagnosis of GRDs can be challenging because the typical and atypical clinical manifestations of the GRDs overlap. In this review, the current definitions of gluten-related disorders, focusing on their clinical features, diagnostic and therapeutic approaches are presented. We concluded that GRDs are usually diagnosed using a combination of clinical features, serological tests, and histopathological findings. Treatment usually involves dietary modification.
Funder
Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology,General Medicine
Reference163 articles.
1. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012;10(1):1–12.
2. Rostami-Nejad M, Karkhane M, Marzban A, Mojarad EN, Rostami K. Gluten related disorders. Gastroenterology and hepatology from bed to bench. 2012;5(Suppl 1):S1.
3. Sharma N, Bhatia S, Chunduri V, Kaur S, Sharma S, Kapoor P, et al. Pathogenesis of celiac disease and other gluten related disorders in wheat and strategies for mitigating them. Frontiers in Nutrition. 2020;7.
4. Bascuñán Gamboa K, Roncoroni L, Branchi F, Doneda L, Scricciolo A, Ferretti F, et al. The 5 Ws of a gluten challenge for gluten-related disorders. Nutr Rev. 2018;76.
5. Tovoli F, Masi C, Guidetti E, Negrini G, Paterini P, Bolondi L. Clinical and diagnostic aspects of gluten related disorders. World journal of clinical cases. 2015;3:275–84.
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