Author:
Mauki David H.,Tijjani Abdulfatai,Ma Cheng,Ng’ang’a Said I.,Mark Akanbi I.,Sanke Oscar J.,Abdussamad Abdussamad M.,Olaogun Sunday C.,Ibrahim Jebi,Dawuda Philip M.,Mangbon Godwin F.,Kazwala Rudovick R.,Gwakisa Paul S.,Yin Ting-Ting,Li Yan,Peng Min-Sheng,Adeola Adeniyi C.,Zhang Ya-Ping
Abstract
AbstractBackgroundCattle are considered to be the most desirable livestock by small scale farmers. In Africa, although comprehensive genomic studies have been carried out on cattle, the genetic variations in indigenous cattle from Nigeria have not been fully explored. In this study, genome-wide analysis based on genotyping-by-sequencing (GBS) of 193 Nigerian cattle was used to reveal new insights on the history of West African cattle and their adaptation to the tropical African environment, particularly in sub-Saharan region. ResultsThe GBS data were evaluated against whole-genome sequencing (WGS) data and high rate of variant concordance between the two platforms was evident with high correlated genetic distance matrices genotyped by both methods suggestive of the reliability of GBS applicability in population genetics. The genetic structure of Nigerian cattle was observed to be homogenous and unique from other African cattle populations. Selection analysis for the genomic regions harboring imprints of adaptation revealed genes associated with immune responses, growth and reproduction, efficiency of feeds utilization, and heat tolerance. Our findings depict potential convergent adaptation between African cattle, dogs and humans with adaptive genesSPRY2andITGB1BP1possibly involved in common physiological activities.ConclusionThe study presents unique genetic patterns of Nigerian cattle which provide new insights on the history of cattle in West Africa based on their population structure and the possibility of parallel adaptation between African cattle, dogs and humans in Africa which require further investigations.
Publisher
Springer Science and Business Media LLC
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献