Author:
Wang Fu-Lin,Wang Wan-Zhou,Zhang Fei-Fei,Peng Su-Yuan,Wang Huai-Yu,Chen Rui,Wang Jin-Wei,Li Peng-Fei,Wang Yang,Zhao Ming-Hui,Yang Chao,Zhang Lu-Xia
Abstract
Abstract
Background
Climate change profoundly shapes the population health at the global scale. However, there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease (CKD).
Methods
In the present study, we studied the association of heat exposure with hospitalizations for cause-specific CKD using a national inpatient database in China during the study period of hot season from 2015 to 2018. Standard time-series regression models and random-effects meta-analysis were developed to estimate the city-specific and national averaged associations at a 7 lag-day span, respectively.
Results
A total of 768,129 hospitalizations for CKD was recorded during the study period. The results showed that higher temperature was associated with elevated risk of hospitalizations for CKD, especially in sub-tropical cities. With a 1 °C increase in daily mean temperature, the cumulative relative risks (RR) over lag 0–7 d were 1.008 [95% confidence interval (CI) 1.003–1.012] for nationwide. The attributable fraction of CKD hospitalizations due to high temperatures was 5.50%. Stronger associations were observed among younger patients and those with obstructive nephropathy. Our study also found that exposure to heatwaves was associated with added risk of hospitalizations for CKD compared to non-heatwave days (RR = 1.116, 95% CI 1.069–1.166) above the effect of daily mean temperature.
Conclusions
Short-term heat exposure may increase the risk of hospitalization for CKD. Our findings provide insights into the health effects of climate change and suggest the necessity of guided protection strategies against the adverse effects of high temperatures.
Funder
National Natural Science Foundation of China
National Key R&D Program of the Ministry of Science and Technology of China
Chinese Scientific and Technical Innovation Project 2030
National High Level Hospital Clinical Research Funding
CAMS Innovation Fund for Medical Sciences
Young Elite Scientists Sponsorship Program by CAST
PKU-Baidu Fund
Publisher
Springer Science and Business Media LLC
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