Author:
Latifovic Lidija, ,Villeneuve Paul J.,Parent Marie-Élise,Kachuri Linda,Harris Shelley A.
Abstract
Abstract
Background
Silica and asbestos are recognized lung carcinogens. However, their role in carcinogenesis at other organs is less clear. Clearance of inhaled silica particles and asbestos fibers from the lungs may lead to translocation to sites such as the bladder where they may initiate carcinogenesis. We used data from a Canadian population-based case-control study to evaluate the associations between these workplace exposures and bladder cancer.
Methods
Data from a population-based case-control study were used to characterize associations between workplace exposure to silica and asbestos and bladder cancer among men. Bladder cancer cases (N = 658) and age-frequency matched controls (N = 1360) were recruited within the National Enhanced Cancer Surveillance System from eight Canadian provinces (1994–97). Exposure concentration, frequency and reliability for silica and asbestos were assigned to each job, based on lifetime occupational histories, using a combination of job-exposure profiles and expert review. Exposure was modeled as ever/never, highest attained concentration, duration (years), highest attained frequency (% worktime) and cumulative exposure. Odds ratios (OR) and their 95% confidence intervals (CI) were estimated using adjusted logistic regression.
Results
A modest (approximately 20%) increase in bladder cancer risk was found for ever having been exposed to silica, highest attained concentration and frequency of exposure but this increase was not statistically significant. Relative to unexposed, the odds of bladder cancer were 1.41 (95%CI: 1.01–1.98) times higher among men exposed to silica at work for ≥27 years. For asbestos, relative to unexposed, an increased risk of bladder cancer was observed for those first exposed ≥20 years ago (OR:2.04, 95%CI:1.25–3.34), those with a frequency of exposure of 5–30% of worktime (OR:1.45, 95%CI:1.06–1.98), and for those with < 10 years of exposure at low concentrations (OR:1.75, 95%CI:1.10–2.77) and the lower tertile of cumulative exposure (OR:1.69, 95%CI:1.07–2.65). However, no clear exposure-response relationships emerged.
Conclusions
Our results indicate a slight increase in risk of bladder cancer with exposure to silica and asbestos, suggesting that the effects of these agents are broader than currently recognized. The findings from this study inform evidence-based action to enhance cancer prevention efforts, particularly for workers in industries with regular exposure.
Funder
Workplace Safety and Insurance Board
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Reference60 articles.
1. Guha N, Straif K, Benbrahim-Tallaa L. The IARC monographs on the carcinogenicity of crystalline silica. Med Lav. 2011;102(4):310–20.
2. Steenland K, Ward E. Silica: a lung carcinogen. CA Cancer J Clin. 2014;64(1):63–9.
3. CAREX. Silica (Crystalline) Canada: CAREX; 2018 [Available from: https://www.carexcanada.ca/en/silica_(crystalline). Accessed 5 Sept 2018.
4. OSHA. Workers' Exposure to Respirable Crystalline Silica: Final Rule Overview: U.S. Department of Labor; 2016 [Available from: https://www.osha.gov/Publications/OSHA3683.pdf. Accessed 5 Sept 2018.
5. Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, et al. Occupational exposure to carcinogens in the European Union. Occup Environ Med. 2000;57(1):10–8.
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