MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation
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Published:2023-10-09
Issue:1
Volume:23
Page:
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ISSN:1471-2407
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Container-title:BMC Cancer
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language:en
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Short-container-title:BMC Cancer
Author:
Zhenhai Zou,Qi Cheng,Shuchao Zhang,Zhongqi Wang,Xue Song,Zhijun Geng,Zhijie Mei,Jianmin Liu,Beibei Liu,Yuanyuan Guo
Abstract
AbstractMicroRNAs (miRNAs) have been reported to serve as potential biomarkers in bladder cancer and play important roles in cancer progression. This study aimed to investigate the biological role of miR-205-3p in bladder cancer. We showed that miR-205-3p was significantly down-regulated in bladder cancer tissues and cells. Moreover, overexpression of miR-205-3p inhibited bladder cancer progression in vitro. Then we confirmed that GLO1, a downstream target of miR-205-3p, mediated the effect of miR-205-3p on bladder cancer cells. In addition, we found that miR-205-3p inhibits P38/ERK activation through repressing GLO1. Eventually, we confirmed that miR-205-3p inhibits the occurrence and progress of bladder cancer by targeting GLO1 in vivo by nude mouse tumorigenesis and immunohistochemistry. In a word, miR-205-3p inhibits proliferation and metastasis of bladder cancer cells by activating the GLO1 mediated P38/ERK signaling pathway and that may be a potential therapeutic target for bladder cancer.
Funder
National Natural Science Foundation of China
The Key Projects of Natural Science Research Project of Anhui Educational Committee
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
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