Author:
Yang Yueyang,Tang Peng,Ma Mingquan,Zhang Hongdian,Wang Haitong,Zhu Kai,Xiao Wanyi,Gong Lei,Yu Zhentao
Abstract
Abstract
Background
Synchronous multiple primary esophageal squamous cell carcinoma (S-MPESCC) refers to more than one primary esophageal carcinoma detected in a solitary patient at the time of initial presentation. The purpose of this study was to evaluate the clinicopathological features, appropriate surgical approaches and long-term survival in patients with S-MPESCC by comparing with those with solitary esophageal squamous cell carcinoma (SESCC).
Methods
In total, 567 patients with esophageal squamous cell carcinoma surgically resected in Tianjin Medical University Cancer Institute and Hospital from January 2012 to December 2018 were screened for retrospective analysis (50 in the S-MPESCC group and 516 in the SESCC group).
Results
No significant difference was observed in terms of other characteristics except total alcohol consumption (P = 0.029). S-MPESCC had higher lymph node rate than SESCC (62.0% and 44.1%, respectively; P = 0.015) especially in upper mediastinal (32.0% and 18.6%, respectively; P = 0.023) and abdominal (38.0% and 22.8%, respectively; P = 0.017) regions. The survival was not different between the two groups, and the 5-year survival rates of S-MPESCC and SESCC were 46.2% and 50.8%, respectively (P = 0.507). But for patients with pT3-4 cancers, the survival in S-MPESCC was worse than that in SESCC (P = 0.033). In the multivariate analysis, pT stage of primary cancer was an important independent predictor of prognosis in patients with S-MPESCC (hazard ratio [HR], 3.968; 95% confidence interval [CI], 1.031 to 15.268; P = 0.045).
Conclusions
S-MPESCC was significantly different from SESCC in terms of clinicopathological characteristics include alcohol intake and pattern of lymphatic metastasis. Furthermore, S-MPESCC showed worse long-term survival than SESCC with increasing depth of primary cancer infiltration.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Reference43 articles.
1. Chen Z, Li S, He Z, Li G. Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas. Korean J Intern Med. 2021;36(6):1356–64.
2. Petroianu A, Sabino KR, Nunes MB. Synchronous triple squamous cell carcinoma of the esophagus. Int J Surg Case Rep. 2018;49:34–6.
3. Lee GD, Kim YH, Kim JB, Choi SH, Kim HR, Kim DK, Park SI. Esophageal cancer associated with multiple primary cancers: surgical approaches and long-term survival. Ann Surg Oncol. 2013;20(13):4260–6.
4. Otowa Y, Nakamura T, Takiguchi G, Yamamoto M, Kanaji S, Imanishi T, Oshikiri T, Suzuki S, Tanaka K, Kakeji Y. Safety and benefit of curative surgical resection for esophageal squamous cell cancer associated with multiple primary cancers. Eur J Surg Oncol. 2016;42(3):407–11.
5. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer-Am Cancer Soc. 1953;6(5):963–8.
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