Author:
Almangush Alhadi,Bello Ibrahim O.,Elseragy Amr,Hagström Jaana,Haglund Caj,Kowalski Luiz Paulo,Nieminen Pentti,Coletta Ricardo D.,Mäkitie Antti A.,Salo Tuula,Leivo Ilmo
Abstract
Abstract
Background
The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC).
Methods
A total of 310 cases of early (cT1-2N0) OTSCC were included in this multicenter study. Assessment of TLSs was conducted on hematoxylin and eosin-stained sections. TLSs were assessed both in the central part of the tumor and at the invasive front area.
Results
The presence of TLSs associated with improved survival of early OTSCC as presented by Kaplan–Meier survival analyses for disease-specific survival (P = 0.01) and overall survival (P = 0.006). In multivariable analyses, which included conventional prognostic factors, the absence of TLSs associated with worse disease-specific survival with a hazard ratio (HR) of 1.96 (95% CI 1.09–3.54; P = 0.025) and poor overall survival (HR 1.66, 95% CI 1.11–2.48; P = 0.014).
Conclusion
Histological evaluation of TLSs predicts survival in early OTSCC. TLSs showed superior prognostic power independent of routine WHO grading and TNM staging system.
Funder
Finnish Dental Society
K. Albin Johanssons Stiftelse
Helsinki University Hospital Research Fund
Turku University Hospital Fund
Finnish Cancer Society
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Cited by
3 articles.
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