Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

Author:

Ai Xinghao,Mao Feng,Shen Shengping,Shentu Yang,Wang Jiejun,Lu Shun

Funder

Major Key Project of Shanghai Chest Hospital Science & Technology foundation

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Reference34 articles.

1. Zheng R, Zeng H, Zhang S, Fan Y, Qiao Y, Zhou Q, et al. Lung cancer incidence and mortality in China, 2010. Thoracic Cancer. 2016;7(1):94–99.

2. Hermann TW, Yen W-C, Tooker P, Fan B, Roegner K, Negro-Vilar A, et al. The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells. Lung Cancer. 2005;50:9–18.

3. Rizvi NA, Marshall JL, Dahut W, Ness E, Truglia JA, Loewen G, et al. A phase I study of LGD1069 in adults with advanced cancer. Clin Cancer Res. 1999;5:1658–64.

4. Miller VA, Benedetti FM, Rigas JR, Verret AL, Pfister DG, Straus D, et al. Initial clinical trial of a selective retinoid X receptor ligand, LGD1069. J Clin Oncol. 1997;15:790–5.

5. Luo W, Schork NJ, Marschke KB, Ng S-C, Hermann TW, Zhang J, et al. Identification of polymorphisms associated with hypertriglyceridemia and prolonged survival induced by bexarotene in treating non-small cell lung cancer. Anticancer Res. 2011;31:2303–11.

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