Author:
Joseph Gabby B.,McCulloch Charles E.,Nevitt Michael C.,Lynch John,Lane Nancy E.,Pedoia Valentina,Majumdar Sharmila,Link Thomas M.
Abstract
AbstractBackgroundTo assess the compound effects of BMI and sustained depressive symptoms on changes in knee structure, cartilage composition, and knee pain over 4 years using statistical interaction analyses.MethodsOne thousand eight hundred forty-four individuals from the Osteoarthritis Initiative Database were analyzed at baseline and 4-year follow-up. Individuals were categorized according to their BMI and presence of depressive symptoms (based on the Center for Epidemiological Studies Depression Scale (threshold≥16)) at baseline and 4-year follow-up. 3 T MRI was used to quantify knee cartilage T2over 4 years, while radiographs were used to assess joint space narrowing (JSN). Mixed effects models examined the effect of BMI-depressive symptoms interactions on outcomes of cartilage T2, JSN, and knee pain over 4-years.ResultsThe BMI-depressive symptoms interaction was significantly associated with knee pain (p < 0.001) changes over 4 years, but not with changes in cartilage T2(p = 0.27). In women, the BMI-depressive symptoms interaction was significantly associated with JSN (p = 0.01). In a group-based analysis, participants with obesity and depression had significantly greater 4-year changes in knee pain (coeff.(obesity + depression vs. no_obesity + no_depression) = 4.09, 95%CI = 3.60–4.58,p < 0.001), JSN (coeff. = 0.60, 95%CI = 0.44–0.77,p < 0.001), and cartilage T2(coeff. = 1.09, 95%CI = 0.68–1.49,p < 0.001) than participants without depression and normal BMI.ConclusionsThecompoundeffects of obesity and depression have greater impact on knee pain and JSN progression compared to what would be expected based on theirindividualeffects.
Funder
National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
Orthopedics and Sports Medicine,Rheumatology
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