Author:
Wang Wei,Shi Wei,Wang Yinglan,Yang Yane,Li Ping,Zeng Zhipeng,Hu Wenlong,Chen Yumei,Tang Donge,Dai Yong
Abstract
AbstractLung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue.
Funder
Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine, Science and Technology Planning Project of Guangdong Province, China
Sanming project of medicine in Shenzhen
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Biochemistry