Author:
Al-Awsi Ghaidaa Raheem Lateef,Alsaikhan Fahad,Margiana Ria,Ahmad Irfan,Patra Indrajit,Najm Mazin A. A.,Yasin Ghulam,Rasulova Iroda,Hammid Ali Thaeer,Kzar Hamzah H.,Al-Gazally Moaed E.,Siahmansouri Homayoon
Abstract
AbstractIn women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC.
Funder
Scientific Research Deanship at King Khalid University, Abha, Saudi Arabia
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Medicine,Medicine (miscellaneous)
Cited by
4 articles.
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