Author:
Perea-Gil Isaac,Prat-Vidal Cristina,Bayes-Genis Antoni
Abstract
AbstractTreating a myocardial infarction (MI), the most frequent cause of death worldwide, remains one of the most exciting medical challenges in the 21st century. Cardiac tissue engineering, a novel emerging treatment, involves the use of therapeutic cells supported by a scaffold for regenerating the infarcted area. It is essential to select the appropriate scaffold material; the ideal one should provide a suitable cellular microenvironment, mimic the native myocardium, and allow mechanical and electrical coupling with host tissues. Among available scaffold materials, natural scaffolds are preferable for achieving these purposes because they possess myocardial extracellular matrix properties and structures. Here, we review several natural scaffolds for applications in MI management, with a focus on pre-clinical studies and clinical trials performed to date. We also evaluate scaffolds combined with different cell types and proteins for their ability to promote improved heart function, contractility and neovascularization, and attenuate adverse ventricular remodeling. Although further refinement is necessary in the coming years, promising results indicate that natural scaffolds may be a valuable translational therapeutic option with clinical impact in MI repair.
Funder
Red de Investigación Cardiovascular
Red de Investigación en Terapia Celular-TerCel
Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación
Fundació Privada Daniel Bravo Andreu
La Marató de TV3
Medical Sciences and Health Academy of Catalonia and Balearics
Catalan Society of Cardiology
Spanish Society of Cardiology
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Medicine,Medicine (miscellaneous)
Cited by
54 articles.
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