Abstract
Abstract
Background
Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to study the dynamics and trends of malaria transmission at the China–Myanmar border to provide epidemiologic information for improved malaria control.
Methods
PCD was conducted in one hospital and 12 clinics near the Laiza town in northeast Myanmar from 2011 to 2016. Clinical malaria was diagnosed by microscopy and demographic information was captured using a structured questionnaire at the time of the patient’s presentation for care.
Results
Over the study period, 6175 (19.7%) malaria cases were confirmed by microscopy from 31,326 suspected cases. The four human malaria parasite species were all identified, with Plasmodium vivax and Plasmodium falciparum accounting for 5607 (90.8%) and 481 (7.8%) of the confirmed cases, respectively. In contrast to the steady decline of malaria in the general GMS, the study site had an upward trend of malaria incidence with vivax malaria outbreaks in 2013 and 2016. Adult males, children under the age of 15, and those with occupations such as farming, being a soldier or student, had significantly higher risks of clinical malaria compared to having fevers from other aetiologies. A self-reported history of clinical malaria was also associated with a higher risk of confirmed malaria.
Conclusions
The China–Myanmar border area has experienced an overall upward trend of malaria incidence in recent years with P. vivax becoming the predominant species. Evidence-based control strategies need to focus on high-risk populations.
Funder
National Institutes of Health
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Parasitology
Reference20 articles.
1. WHO. World malaria report 2017. Geneva: World Health Organization; 2018.
2. WHO. Eliminating malaria in the Greater Mekong Subregion: United to end a deadly disease. Geneva: World Health Organization; 2016.
https://www.whoint/malaria/publications/atoz/eliminating-malaria-greater-mekong/en/
.
3. Zhang J, Dong JQ, Li JY, Zhang Y, Tian YH, Sun XY, et al. Effectiveness and impact of the cross-border healthcare model as implemented by non-governmental organizations: case study of the malaria control programs by health poverty action on the China–Myanmar border. Infect Dis Poverty. 2016;5:80.
4. Cui L, Yan G, Sattabongkot J, Chen B, Cao Y, Fan Q, et al. Challenges and prospects for malaria elimination in the Greater Mekong Subregion. Acta Trop. 2012;121:240–5.
5. Parker DM, Carrara VI, Pukrittayakamee S, McGready R, Nosten FH. Malaria ecology along the Thailand–Myanmar border. Malar J. 2015;14:388.
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