Author:
Liao Xuejiao,Li Dapeng,Liu Jie,Liu Zhi,Ma Zhenghua,Dong Jingke,Yang Xiangyi,Shu Dan,Yuan Jing,Liu Lei,Zhang Zheng
Abstract
Abstract
Background
Clinical data on patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant are limited, especially on clinical status after the application of antibody therapy.
Methods
We evaluated clinical status in patients with the SARS-CoV-2 delta variant after BRII-196 and BRII-198 treatment in an infectious disease hospital in China. We collected data on clinical symptoms, laboratory tests, radiological characteristics, viral load, anti-SARS-CoV-2 antibodies, treatment, and outcome.
Results
In mid-June 2021, 36 patients with delta variant infection were identified in Shenzhen. The most common symptoms at illness onset were cough (30.6%), fever (22.2%), myalgia (16.7%), and fatigue (16.7%). A small number of patients in this study had underlying diseases, including diabetes (5.6%) and hypertension (8.3%). The application of BRII-196 and BRII-198 can rapidly increase anti-SARS-CoV-2 IgG. The median peak IgG levels in the antibody treatment group were 32 times higher than those in the control group (P < 0.001). The time from admission to peak IgG levels in the antibody treatment group (mean: 10.2 days) was significantly shorter than that in the control group (mean: 17.7 days). Chest CT score dropped rapidly after antibody therapy, with a mean duration of 5.74 days from admission to peak levels.
Conclusion
The results of this study suggest that the application of BRII-196 and BRII-198 antibody therapy improved clinical status in patients with SARS-CoV-2 delta variant infection.
Funder
Science and Technology Innovation Committee of Shenzhen Municipality
Emergency Key Program of Guangzhou Laboratory
National Science Fund for Distinguished Young Scholars
Central Charity Fund of Chinese Academy of Medical Science
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology