Author:
Chen Yi,Cao Zhiqiang,Li Jianjun,Chen Jin,Zhu Qiuying,Liang Shujia,Lan Guanghua,Xing Hui,Liao Lingjie,Feng Yi,Shao Yiming,Ruan Yuhua,Chen Huanhuan
Abstract
Abstract
Objectives
To evaluate the prevention efficacy of scaling up HIV/AIDS antiretroviral therapy (ART) on HIV transmission at the population level and determine associated factors of HIV secondary transmission.
Methods
We used HIV longitudinal molecular networks to assess the genetic linkage between baseline and newly diagnosed cases. A generalized estimating equation was applied to determine the associations between demographic, clinical characteristics and HIV transmission.
Results
Patients on ART had a 32% lower risk of HIV transmission than those not on ART. A 36% reduction in risk was also seen if ART-patients maintained their HIV viral load lower than 50 copies/mL. A 71% lower risk occurred when patients sustained ART for at least 3 years and kept HIV viral load less than 50 copies/mL. Patients who discontinued ART had a similar HIV transmission risk as those not on ART. Patients who were older, male, non-Han, not single, retired, infected via a heterosexual route of transmission and those who possessed higher CD4 counts had a higher risk of HIV transmission. HIV-1 subtype of CRF01_AE was less transmissible than other subtypes.
Conclusions
The efficacy of ART in a real-world setting was supported by this longitudinal molecular network study. Promoting adherence to ART is crucial to reduce HIV transmission.
Funder
National Natural Science Foundation of China
Guangxi Natural Science Foundation Project
Guangxi Key Laboratory of AIDS Prevention Control and Translation
Guangxi Medical and health key discipline construction project
Ministry of Science and Technology of China
Chinese State Key Laboratory of Infectious Disease Prevention and Control
Guangxi Bagui Honor Scholarship
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology