Author:
Zhao Jingyu,Zhang Xinyue,Fang Liwei,Pan Hong,Shi Jun
Abstract
Abstract
Background
Interleukin (IL) 28B polymorphisms encoding pro-inflammatory and anti-inflammatory cytokines trigger diverse clinical outcome of hepatitis virus infection. However, there is controversy concerning the association of IL28B polymorphisms with the outcome of hepatitis B virus (HBV) infection, with several studies obtaining inconsistent results. We performed a meta-analysis to evaluate the role of 3 single nucleotide polymorphisms (SNPs) rs12979860, rs12980275 and rs8099917 in the progression of HBV infection, overall and by ethnicity.
Methods
Searched PubMed, Embase and Wiley Online Library electronic databases using ‘interleukin 28B’, ‘IL 28B’, ‘IL 28B polymorphism’, ‘hepatitis B virus’, ‘HBV’, and performed meta- analysis for rs12979860, rs12980275 and rs8099917 in Asian and Caucasian populations under the dominant recessive and allele model.
Results
Eighteen studies were found in total and used for this meta-analysis, including 5587 cases and 4295 controls. The IL28B polymorphism rs12979860 had no association with HBV persistence (CC vs CT + TT: OR = 0.86, 95% CI = 0.76–1.00; TT vs CT + CC: OR = 1.14, 95% CI = 0.76–1.70; T vs C: OR = 1.03, 95% CI = 0.94–1.13). Similarly, neither rs12980275 nor rs8099917 had associations with HBV persistence (rs12980275 in AA vs AG + AA: OR = 1.15, 95% CI = 0.96–1.38; rs8099917 in TT vs GT + GG: OR = 1.15, 95% CI = 0.96–1.39). There was also no significant association of IL28B polymorphisms with persistent HBV infection in Asians or Chinese. There was no evidence of an association of rs12979860 with the HBV-related hepatocellular carcinoma susceptibility (T vs C: OR = 1.53, 95% CI = 0.96–2.43).
Conclusion
IL28B polymorphisms had no association with the outcome of HBV infection overall, nor in the Asians and the Chinese. These 3 SNPs might not be relevant to the development of HBV infection.
Funder
CAMS Innovation Fund for Medical Sciences
Tianjin Municipal Science and Technology Commission Major Project
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics
Cited by
11 articles.
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