Animal models of primary biliary cholangitis: status and challenges

Author:

Wang Xu,Wei Yi,Yang Yanlei,Yang Yunjiao,Li Haolong,Li Yongzhe,Zhang Fengchun,Wang LiORCID

Abstract

Abstract Background Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenesis is complex. Animal models are essential to clarify the pathogenesis of PBC and explore the occurrence of early events. Main body Herein, we review recent research progress in PBC animal models, including genetically modified, chemically inducible, biologically inducible, and protein-immunised models. Although these animal models exhibit several immunological and pathological features of PBC, they all have limitations that constrain further research and weaken their connection with clinical practice. Conclusion The review will benefit efforts to understand and optimise animal models in order to further clarify PBC pathogenesis and molecular targets for therapeutic interventions.

Funder

National Key Research and Development Program of China

Ministry of Science and Technology of the People's Republic of China

Special Funds for the Basic Research and Development Program in the Central Non-profit Research Institutesof China

Yalong River Joint Fund

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology

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