Abstract
Abstract
Background
Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenesis is complex. Animal models are essential to clarify the pathogenesis of PBC and explore the occurrence of early events.
Main body
Herein, we review recent research progress in PBC animal models, including genetically modified, chemically inducible, biologically inducible, and protein-immunised models. Although these animal models exhibit several immunological and pathological features of PBC, they all have limitations that constrain further research and weaken their connection with clinical practice.
Conclusion
The review will benefit efforts to understand and optimise animal models in order to further clarify PBC pathogenesis and molecular targets for therapeutic interventions.
Funder
National Key Research and Development Program of China
Ministry of Science and Technology of the People's Republic of China
Special Funds for the Basic Research and Development Program in the Central Non-profit Research Institutesof China
Yalong River Joint Fund
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology