Abstract
AbstractNovel endoscopic biophotonic diagnostic technologies have the potential to non-invasively detect the interior of a hollow organ or cavity of the human body with subcellular resolution or to obtain biochemical information about tissue in real time. With the capability to visualize or analyze the diagnostic target in vivo, these techniques gradually developed as potential candidates to challenge histopathology which remains the gold standard for diagnosis. Consequently, many innovative endoscopic diagnostic techniques have succeeded in detection, characterization, and confirmation: the three critical steps for routine endoscopic diagnosis. In this review, we mainly summarize researches on emerging endoscopic optical diagnostic techniques, with emphasis on recent advances. We also introduce the fundamental principles and the development of those techniques and compare their characteristics. Especially, we shed light on the merit of novel endoscopic imaging technologies in medical research. For example, hyperspectral imaging and Raman spectroscopy provide direct molecular information, while optical coherence tomography and multi-photo endomicroscopy offer a more extensive detection range and excellent spatial–temporal resolution. Furthermore, we summarize the unexplored application fields of these endoscopic optical techniques in major hospital departments for biomedical researchers. Finally, we provide a brief overview of the future perspectives, as well as bottlenecks of those endoscopic optical diagnostic technologies. We believe all these efforts will enrich the diagnostic toolbox for endoscopists, enhance diagnostic efficiency, and reduce the rate of missed diagnosis and misdiagnosis.
Funder
Ministry of Science and Technology of the People's Republic of China
National Key Scientific Instrument and Equipment Development Projects of China
the Robotics Institute of Zhejiang University
the Key Research and Development Plan of Zhejiang Province
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Biomedical Engineering,General Medicine,Biomaterials,Radiological and Ultrasound Technology
Reference228 articles.
1. Association BM, Smith T. The British Medical Association Complete Family Health Encyclopedia Complete Family Health Encyclopedia: Dorling Kindersley; 1990.
2. Groen PCD. History of the Endoscope Proceedings of the IEEE. 2017;105:1987–95.
3. Sabina B, Ana W, Krish R. The use of optical imaging techniques in the gastrointestinal tract. Frontline Gastroenterology. 2016;7:207–15.
4. Song LMWK, Adler DG, Conway JD, Diehl DL, Farraye FA, Kantsevoy SV, et al. Narrow band imaging and multiband imaging. Gastrointest Endosc. 2008;67:581–9.
5. Kuznetsov K, Lambert R, Rey JF. Narrow-band imaging: potential and limitations. Endoscopy. 2006;38:76–81.
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