Author:
Zhang Jing,Summah Hanssa,Zhu Ying-gang,Qu Jie-Ming
Abstract
Abstract
Background
Only 10-15% of smokers develop chronic obstructive pulmonary disease (COPD) which indicates genetic susceptibility to the disease. Recent studies suggested an association between COPD and polymorphisms in CHRNA coding subunits of nicotinic acetylcholine receptor. Herein, we performed a meta-analysis to clarify the impact of CHRNA variants on COPD.
Methods
We searched Web of Knowledge and Medline from 1990 through June 2011 for COPD gene studies reporting variants on CHRNA. Pooled odds ratios (ORs) were calculated using the major allele or genotype as reference group.
Results
Among seven reported variants in CHRNA, rs1051730 was finally analyzed with sufficient studies. Totally 3460 COPD and 11437 controls from 7 individual studies were pooled-analyzed. A-allele of rs1051730 was associated with an increased risk of COPD regardless of smoking exposure (pooled OR = 1.26, 95% CI 1.18-1.34, p < 10-5). At the genotypic level, the ORs gradually increased per A-allele (OR = 1.27 and 1.50 for GA and AA respectively, p < 10-5). Besides, AA genotype exhibited an association with reduced FEV1% predicted (mean difference 3.51%, 95%CI 0.87-6.16%, p = 0.009) and increased risk of emphysema (OR 1.93, 95%CI 1.29-2.90, p = 0.001).
Conclusions
Our findings suggest that rs1051730 in CHRNA is a susceptibility variant for COPD, in terms of both airway obstruction and parenchyma destruction.
Publisher
Springer Science and Business Media LLC
Reference40 articles.
1. Global Initiative for Chronic Obstructive Lung Disease: Workshop report: global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease [internet] (updated 2009). Available from: http://www.goldcopd.org/
2. Hogg JC, Timens W: The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 2009, 4: 435-459. 10.1146/annurev.pathol.4.110807.092145.
3. Fletcher C, Peto R: The natural history of chronic airflow obstruction. Br Med J. 1977, 1: 1645-1648. 10.1136/bmj.1.6077.1645.
4. Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC: Surveillance for asthma--United States, 1980-1999. MMWR Surveill Summ. 2002, 51: 1-13.
5. Smolonska J, Wijmenga C, Postma DS, Boezen HM: Meta-analyses on Suspected Chronic Obstructive Pulmonary Disease Genes: A Summary of 20 Years' Research. Am J Respir Crit Care Med. 2009, 180: 618-631. 10.1164/rccm.200905-0722OC.
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