Author:
Shaker Ali,Shekari Soheila,Zeinalabedini Mobina,Salimi Zahra,Roumi Zahra,Mobarakeh Khadijeh Abbasi,Shamsi-Goushki Ali,Masoumvand Mohammad,Keshavarz Mohammadian Mohammad,Samani Pegah,Azizi-Tabesh Ghasem,Shafaei Hanieh,Doaei Saeid,Kalantari Naser,Gholamalizadeh Maryam
Abstract
Abstract
Background
Single Nucleotide Polymorphisms (SNPs) of the Fat mass and obesity-associated (FTO) gene may be associated with obesity by regulating appetite. The present study aimed to investigate the relationship between FTO genotype and resistance to eating in male adolescents.
Methods
The present cross-sectional study included 246 adolescent boys in Tehran, Iran, who were assessed for self-efficacy related to weight control using the Weight Efficacy Lifestyle (WEL), questionnaire, food intake using the Food Frequency Questionnaire (FFQ), physical activity using the International Physical Activity Questionnaire (IPAQ), and anthropometric indices using Bio-Impedance Analyzer (BIA). Moreover, the participants underwent genotyping for the rs9930506 polymorphism of the FTO gene, and the relationship between FTO genotype and resistance to eating was investigated using different models of multiple linear regression.
Results
According to our findings, there was a significant reverse relationship between the FTO rs9930506 genotype and resistance to eating (β: -0.16, P = 0.01). Moreover, the relationship was still significant after adjusting for age, nutritional knowledge, BMI, and mother’s BMI, educational level, and occupational status.
Conclusion
According to our results, the FTO genotype had a significant effect on resistance to eating and food desires. However, there is a need for further studies to evaluate the underlying mechanisms of the effects of the FTO gene on appetite and obesity.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
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