Author:
Xu Xiaodan,Wang Xueting,Ding Meiyun,Zhao Yilin,Zhao Li,Zhao Linsheng,Li Mengdi,Zhao Fangyuan,Sun Rongjuan,Wang Zhiru,Zhang Ruifeng,Zhang Shujian,Ge Liang,Sun Yan,Zhan Jianghua
Abstract
Abstract
Objectives
To validate an appropriate evaluation method of liver fibrosis assessment based on the unique pathological features of biliary atresia (BA) that could well predict its prognosis.
Methods
A total of 68 patients with BA who underwent Kasai procedure (KP) and an intraoperative liver biopsy, followed up from January 2019 to December 2021, were recruited in a retrospective analysis. Ishak, Metavir, and BA-specific staging systems in relation to outcomes were analyzed using logistic regression, COX proportional hazard regression, Kaplan-Meier analysis, etc.
Results
Kaplan-Meier analysis determined a significant difference in native liver survival according to the BA-specific stage (p = 0.002). The ROC curve analysis for predicting prognosis showed that the AUC of BA-specific staging combined with iBALF and severe bile duct proliferation (BDP) (0.811, 95% CI: 0.710–0.913, p < 0.0001) was higher than BA-specific staging alone (0.755, 95% CI: 0.639–0.872, p < 0.001).
Conclusions
The BA-specific staging system reflects the condition of the liver fibrosis, and its combination with iBALF and severe BDP helps to better evaluate the prognosis of patients with BA.
Funder
Tianjin Applied Basic Research Project
Tianjin Municipal Science and Technology Bureau Major Projects
Xinjiang Uygur Autonomous Region Science Foundation Projects
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health