Author:
Xu Hongtao,Fang Fang,Wu Kaizhang,Song Jiangping,Li Yaqian,Lu Xingyu,Liu Juncheng,Zhou Liuyang,Yu Wenqing,Yu Fei,Gao Jie
Abstract
Abstract
Background
Diet-induced dyslipidemia is linked to the gut microbiota, but the causality of microbiota-host interaction affecting lipid metabolism remains controversial. Here, the humanized dyslipidemia mice model was successfully built by using fecal microbiota transplantation from dyslipidemic donors (FMT-dd) to study the causal role of gut microbiota in diet-induced dyslipidemia.
Results
We demonstrated that FMT-dd reshaped the gut microbiota of mice by increasing Faecalibaculum and Ruminococcaceae UCG-010, which then elevated serum cholicacid (CA), chenodeoxycholic acid (CDCA), and deoxycholic acid (DCA), reduced bile acid synthesis and increased cholesterol accumulation via the hepatic farnesoid X receptor-small heterodimer partner (FXR-SHP) axis. Nevertheless, high-fat diet led to decreased Muribaculum in the humanized dyslipidemia mice induced by FMT-dd, which resulted in reduced intestinal hyodeoxycholic acid (HDCA), raised bile acid synthesis and increased lipid absorption via the intestinal farnesoid X receptor-fibroblast growth factor 19 (FXR-FGF19) axis.
Conclusions
Our studies implicated that intestinal FXR is responsible for the regulation of lipid metabolism in diet-induced dyslipidemia mediated by gut microbiota-bile acid crosstalk.
Funder
National Natural Science Foundation of China
Specific Research Project of Guangxi for Research Bases and Talents
Publisher
Springer Science and Business Media LLC
Subject
Microbiology (medical),Microbiology
Cited by
1 articles.
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