Mechanism of RNA modification N6-methyladenosine in human cancer


Zhou Zijian,Lv Jiancheng,Yu Hao,Han Jie,Yang Xiao,Feng Dexiang,Wu Qikai,Yuan Baorui,Lu Qiang,Yang HaiweiORCID


AbstractSince the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a predominantly internal epigenetic modification in eukaryotes mRNA, heralded the creation of the field of epi-transcriptomics. This post-transcriptional RNA modification is dynamic and reversible, and is regulated by methylases, demethylases and proteins that preferentially recognize m6A modifications. Altered m6A levels affect RNA processing, degradation and translation, thereby disrupting gene expression and key cellular processes, ultimately resulting in tumor initiation and progression. Furthermore, inhibitors and regulators of m6A-related factors have been explored as therapeutic approaches for treating cancer. In the present review, the mechanisms of m6A RNA modification, the clinicopathological relevance of m6A alterations, the type and frequency of alterations and the multiple functions it regulates in different types of cancer are discussed.


the National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

the Provincial Initiative Program for Excellency Disciplines of Jiangsu Province

the “333” project of Jiangsu Province

Jiangsu Province’s Key Provincial Talents Program


Springer Science and Business Media LLC


Cancer Research,Oncology,Molecular Medicine







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