Author:
Giansanti Manuela,Theinert Tobias,Boeing Sarah Katharina,Haas Dorothee,Schlegel Paul-Gerhardt,Vacca Paola,Nazio Francesca,Caruana Ignazio
Abstract
AbstractAutophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a key role in human health and disease. At present, a growing number of evidence suggests a role of autophagy as a primitive innate immune form of defense for eukaryotic cells, interacting with components of innate immune signaling pathways and regulating thymic selection, antigen presentation, cytokine production and T/NK cell homeostasis. In cancer, autophagy is intimately involved in the immunological control of tumor progression and response to therapy. However, very little is known about the role and impact of autophagy in T and NK cells, the main players in the active fight against infections and tumors. Important questions are emerging: what role does autophagy play on T/NK cells? Could its modulation lead to any advantages? Could specific targeting of autophagy on tumor cells (blocking) and T/NK cells (activation) be a new intervention strategy? In this review, we debate preclinical studies that have identified autophagy as a key regulator of immune responses by modulating the functions of different immune cells and discuss the redundancy or diversity among the subpopulations of both T and NK cells in physiologic context and in cancer.
Funder
Deutsche José Carreras Leukämie-Stiftung” and Gesellschaft für Pädiatrische Onkologie und Hämatologie
AIRC IG2022
Ministero della Salute
AIRC
CureSearch
Elterninitiative Leukämie-und tumorkranker Kinder Würzburg e.V
Aktion Regenbogen für Leukämie-und tumorkranke Kinder Main-Tauber e.V.
Deutsche Forschungsgemeinschaft
Sarcoma Foundation of America
A Collaborative Pediatric Cancer Research Awards Program
John Hansen Research Grant - DKMS Stiftung Leben Spenden
Universitätsklinikum Würzburg
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine