Author:
Soares Guilherme,Pinto Leonardo,Liebl Maik,Biasotti Gabriel,Prospero Andre,Stoppa Erick,Bakuzis Andris,Baffa Oswaldo,Wiekhorst Frank,Miranda José Ricardo Arruda
Abstract
Abstract
Background
Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB), the magnetic nanoparticle's magnetization response under an oscillating magnetic field, which is applied through an excitation coil, is detected with a balanced detection coil system.
Results
We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic nanoparticles spatial distributions in a field of view of 14 × 14 cm2 with a spatial resolution of 2.0 cm and sensitivity in the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle distributions above 0.6 was found for all measurements.
Conclusion
Besides other interesting features such as sufficient large field of view dimension for mice and rat studies, portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an affordable setup for easy access in clinical or laboratory environments.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Pesquisas e Desenvolvimento Tecnológico
Conselho Nacional de Desenvolvimento Científico e Tecnológico
German Academic Exchange program DAAD in cooperation with Brazilian CAPES- PROBRAL
EMPIR program co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation program
DFG project “quantMRX”
DFG core facility
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biomedical Engineering,Environmental Engineering
Cited by
3 articles.
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