Author:
Cauli Elisa,Polidoro Michela Anna,Marzorati Simona,Bernardi Claudio,Rasponi Marco,Lleo Ana
Abstract
AbstractThe approval of anticancer therapeutic strategies is still slowed down by the lack of models able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro models fail to recapitulate the organ and tissue structures, the fluid flows, and the mechanical stimuli characterizing the human body compartments. On the other hand, in vivo animal models cannot reproduce the typical human tumor microenvironment, essential to study cancer behavior and progression. This study reviews the cancer-on-chips as one of the most promising tools to model and investigate the tumor microenvironment and metastasis. We also described how cancer-on-chip devices have been developed and implemented to study the most common primary cancers and their metastatic sites. Pros and cons of this technology are then discussed highlighting the future challenges to close the gap between the pre-clinical and clinical studies and accelerate the approval of new anticancer therapies in humans.
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biomedical Engineering,Environmental Engineering
Cited by
2 articles.
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