Abstract
Abstract
Background
Herpes simplex virus (HSV)-1 is a highly prevalent, non-oncogenic virus that has higher morbidity in immunocompromised hosts. Its most common clinical manifestation is superficial ulceration of the integument or mucus membranes.
Case presentation
A 65-year-old woman with a history of acute myelogenous leukemia treated with allogenic peripheral blood stem cell transplant presented for resection of an ulcerated buccal squamous cell carcinoma. We report a case of HSV-1-infected malignant cells discovered on histopathological examination of the carcinoma specimen ultimately treated with valacyclovir.
Conclusions
HSV-1 is not considered an oncogenic virus itself but may increase risk of malignant progression. Cancer cells are vulnerable to superimposed viral infections, including HSV-1, which likely led to the findings in this case.
Publisher
Springer Science and Business Media LLC
Reference14 articles.
1. Bradley H, Markowitz LE, Gibson T, McQuillan GM. Seroprevalence of herpes simplex virus types 1 and 2–United States, 1999–2010. J Infect Dis. 2014;209(3):325–33. https://doi.org/10.1093/infdis/jit458.
2. Rechenchoski DZ, Faccin-Galhardi LC, Linhares REC, Nozawa C. Herpesvirus: an underestimated virus. Folia Microbiol (Praha). 2017;62(2):151–6. https://doi.org/10.1007/s12223-016-0482-7.
3. Centers for Disease Control and Prevention, Infectious Disease Society of America, American Society of Blood and Marrow Transplantation. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000;49(RR-10):1–125, CE1–7.
4. Duarte LF, Reyes A, Farías MA, et al. Crosstalk between epithelial cells, neurons and immune mediators in HSV-1 skin infection. Front Immunol. 2021;12: 662234. https://doi.org/10.3389/fimmu.2021.662234.
5. Anderson NW, Buchan BW, Ledeboer NA. Light Microscopy, Culture, Molecular, and Serologic Methods for Detection of Herpes Simplex Virus. J Clin Microbiol. 2014;52(1):2–8. https://doi.org/10.1128/JCM.01966-13.
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