Hyaluronic Acid-Functionalized Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging-Guided Radiotherapy of Tumors

Author:

Wu Chaoyang,Cai Rong,Zhao Tian,Wu Lin,Zhang Lirong,Jin Jie,Xu Lixia,Li Pengfei,Li Tao,Zhang Miaomiao,Du Fengyi

Abstract

AbstractInaccuracy localization and intrinsic radioresistance of solid tumors seriously hindered the clinical implementation of radiotherapy. In this study, we fabricated hyaluronic acid-functionalized gadolinium oxide nanoparticles (HA-Gd2O3 NPs) via one-pot hydrothermal process for effective magnetic resonance (MR) imaging and radiosensitization of tumors. By virtue of HA functionalization, the as-prepared HA-Gd2O3 NPs with a diameter of 105 nm showed favorable dispersibility in water, low cytotoxicity, and excellent biocompatibility and readily entered into the cytoplasm of cancer cells by HA receptor-mediated endocytosis. Importantly, HA-Gd2O3 NPs exhibited high longitudinal relaxivity (r1) 6.0 mM−1S−1 as MRI contrast agents and radiosensitization enhancement in a dose-dependent manner. These finds demonstrated that as-synthesized HA-Gd2O3 NPs as bifunctional theranostic agents have great potential in tumors diagnosis and radiotherapy.

Funder

Six talent peaks project in Jiangsu Province

Key talents of Medical Science in Jiangsu Province project

Key research projects of natural science in colleges and universities in jiangsu province

Scientific research projects of college students

Zhenjiang key research and development plan

Major projects of natural science research in Colleges and universities of Jiangsu Province

Publisher

Springer Science and Business Media LLC

Subject

Condensed Matter Physics,General Materials Science

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