Validation of the phenol red thread test in a Chinese population
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Published:2023-12-07
Issue:1
Volume:23
Page:
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ISSN:1471-2415
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Container-title:BMC Ophthalmology
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language:en
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Short-container-title:BMC Ophthalmol
Author:
Hao Yiran,Jin Tao,Zhu Lei,Zhao Mengnan,Wang Silu,Li Zhongying,Tian Lei,Jie Ying
Abstract
Abstract
Background
To investigate the validation of phenol red thread (PRT) test in a Chinese population by evaluating the intraobserver repeatability and interobserver reproducibility, determining correlations between the PRT test and other dry eye disease (DED) parameters including tear meniscus height (TMH) and Schirmer I test, and testing the accuracy of diagnosing DED when using the PRT test alone.
Methods
A total of 108 eyes were involved in this prospective and diagnostic study, and were divided into two groups (with and without DED). Each subject underwent a series of ocular surface examinations, including Ocular Surface Disease Index (OSDI) questionnaire, non-invasive tear breakup time (NIBUT), tear meniscus height (TMH) assessment, PRT test, fluorescein tear breakup time (FBUT), corneal fluorescein staining and Schirmer I test.
Results
In the experimental group and the control group, the intra-class correlation coefficients (ICCs) of the repeatability were 0.747 and 0.723, respectively (all P < 0.05). The ICCs of the reproducibility in both groups were 0.588 and 0.610, respectively (all P < 0.05). The PRT test correlated weakly with the Schirmer I test and the tear meniscus height, with Spearman coefficients of 0.385 and 0.306, respectively (all P < 0.05). The PRT test is available to diagnose DED, with an area under the curve of 0.806 and a Youden index of 0.556 at the cutoff point of 8.83 mm.
Conclusions
The PRT test can provide patients a comfortable, timesaving and less irritating approach to screening and diagnosing DED compared to Schirmer I test.
Funder
National Natural Science Foundation of China Open Research Fund from Beijing Advanced Innovation Center for Big Data-Based Precision Medicine
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,General Medicine
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