Author:
Li Yan Kiu,Fung Nicholas Siu-Kay,Chan Jonathan C.H,Choy Bonnie N.K.,Chow Loraine L.W.,Shih Kendrick C.,Wong Jasper K.W.,Wong Ian Y.H.
Abstract
Abstract
Background/Aims
To assess the normative values and parameters of optical coherence tomography angiography (OCTA) influencing the best corrected visual acuity (BCVA) in adults aged 50 and above.
Methods
This was a prospective cross-sectional study from an eye screening programme in Hong Kong for 4188 citizens aged 50 and above. Images were analysed using a validated quantification software calculating vessel density and capillary perfusion density (CPD), along with other OCTA parameters, such as the foveal avascular zone area (FAZ) and circularity. OCTA data was collected from May 2019 to December 2020, including a total of 4188 healthy eyes from 4188 subjects.
Results
Mean superficial vessel density (MSVD) was 14.48 ± 3.60 mm− 1, while the mean capillary perfusion density (MCPD) was 0.41 ± 0.06. Multivariate analysis revealed ageing (β = 0.321, p < 0.001), being male (β=-0.089, p < 0.001), having a high body mass index (BMI) (β = 0.039, p = 0.006), high FAZ area and low FAZ circularity (β = 0.039 and − 0.034, p = 0.01 and 0.024 respectively), low MSVD in the outer ring (β=-0.513, p < 0.001), specifically in the nasal and temporal outer quadrants (β = -0.226 and − 0.259, p < 0.001 for both), and low MCPD in the outer superior quadrant (β= -0.123, p = 0.016) being independently associated with BCVA.
Conclusion
High FAZ area and low FAZ circularity, low MSVD in the outer ring, specifically the nasal and temporal outer quadrants, and low MCPD in the outer superior quadrant can be used as biomarkers in predicting a low visual acuity in adults aged 50 and above.
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,General Medicine