Author:
Liao Jyh-Fei,Chiou Wen-Fei,Shen Yuh-Chiang,Wang Guei-Jane,Chen Chieh-Fu
Abstract
Abstract
This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. Their potential applications for the treatment of endotoxaemia, obesity, diabetes, Alzheimer's disease and their uses as cardiovascular and gastrointestinal protective agents, analgesics, anti-oxidant, anti-atherosclerosis agents, dermatological agents and anti-infectious agents are highlighted. Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components.
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,Pharmacology
Reference107 articles.
1. Angus DC: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001, 29: 1303-1310. 10.1097/00003246-200107000-00002.
2. Smyth EM, Burke A, Fitzgerald GA: Lipid-derived autacoids: Eicosanoids and platelet-activating factor. Goodman and Gilman's the Pharmacological Basis of Therapeutics. Edited by: Brunton LL, Lazo JS, Parker KL. 2006, New York: McGraw-Hill Med Pub Div, 653-670. 11
3. Elliott MJ, Chitham K, Theoharis LT: The effects of plant flavonoids on mammalian cells. Implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000, 52: 673-751.
4. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991, 43: 109-142.
5. Stefanovic Racic M, Stadler J, Evans CH: Nitric oxide and arthritis. Arthritis Rheum. 1993, 36 (8): 1036-1044. 10.1002/art.1780360803.
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